Anti-Human TfR Recombinant Antibody (3GH7 )
CAT#: TAB-628CT
Recombinant monoclonal antibody has the highest affinity for the TfR. This antibody can be potentially used in treating various human cancers and diseases that express transferrin receptor. It can inhibit the binding of Tf to the TfR.
Tested Data
Gene Expression
SDS-PAGE
Figure 1 Anti-Human TfR Recombinant Antibody (TAB-628CT) in SDS-PAGE
Lane M: Protein Marker
Lane 1: Reducing (2.0ug)
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Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to endosomes & lysosomes.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/28598/546_F8_1_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/207_B2_1_blue_red_green.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/208_B2_1_blue_red_green.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_B_9_5.jpg
Normal Tissue
Figure 5 Colon
Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_A_8_3.jpg
Normal Tissue
Figure 6 Testis
Leydig cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Pachytene spermatocytes
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_A_6_6.jpg
Normal Tissue
Figure 7 Bone marrow
Hematopoietic cells
Staining:
High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_B_6_4.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_A_8_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (HDLM-2)
Cell lines ordered by descending RNA expression order.
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000072274-TFRC
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Specifications
- Host Species
- Human
- Derivation
- Human antibody phage display library
- Type
- Human antibody
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- 3GH7
- Applications
- Used for immunoassay techniques such as: Western Blot
- Related Disease
- Bladder cancer, colon cancer, prostate cancer, and pancreatic cancer
Target
REVIEWS AND Q&AS
CITATIONS
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Integral for Cancer Studies
This Anti-TfR antibody has been integral to our ongoing cancer research. Its precision in binding to transferrin receptors allows for accurate study of cellular processes, significantly contributing to our understanding of tumor biology.
Reliable and High-Quality Results
The consistency and robustness of this antibody have led to high-quality results time after time. It delivers dependable performance across different assays, proving its value and supporting the credibility of our research findings.
Q&As
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What makes this antibody unique for research?
A: This antibody is specially designed to target and bind with high affinity to the transferrin receptor. Its unique construction allows it to specifically interfere with iron uptake pathways, making it invaluable for research in cellular metabolism and oncology.
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Can this product be utilized in clinical settings?
A: No, this antibody is designed solely for research purposes. It provides essential data for pre-clinical explorations but is not approved for therapeutic or clinical use as it requires extensive further verification.
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-628CT, RRID: AB_3111981)
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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- Product Name
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| TAB-611CT-S(P) | Humanized Anti-TFRC Recombinant Antibody; scFv Fragment (TAB-611CT-S(P)) | ELISA | Humanized scFv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC3370 | PE-DRB1*13:02/Human TFRC (NPGGYVAYSKAATVTGKL) MHC Tetramer | FCM | |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0376-CN | Mouse Anti-TFRC Recombinant Antibody (HPAB-0376-CN) | ELISA, FC | Mouse IgG |
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| HPAB-597-FY-S(P) | Human Anti-TFRC Recombinant Antibody; scFv Fragment (HPAB-597-FY-S(P)) | ELISA | Humanized scFv |
| HPAB-0238-YJ-S(P) | Rat Anti-TFRC Recombinant Antibody; scFv Fragment (HPAB-0238-YJ-S(P)) | IHC, FC, WB, FuncS | Rat scFv |
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